What Are The Different Causes Of Lipoma?

Lipoma | Condition | UT Southwestern Medical Center

Are you concerned about the sudden protrusion in your neck or shoulder that keeps you from getting a good night’s sleep? Lipoma may feel like a small pimple at first. As it grows, it becomes rubbery and easily moved with finger pressure. These benign tumors are formed from accumulated fatty cells between the skin and muscle layers.

Rejuvence clinic Lipoma removal eliminates the fat from the lump to relieve any pain or suffering brought on by the lump’s growing size (>2 cm) or location. It is a cosmetic operation performed under local anesthesia using excision or liposuction methods. If it is on the posterior, sleep dyspnea is a common occurrence.

These benign growths might never occur in some individuals. In contrast, others may experience them repeatedly in various body parts depending on their genetic history, gender, activity levels, and so on. While lipomas are generally benign, excessive growth can pressure the nerves, causing a stumbling block in blood circulation and significant damage, which requires different treatments.

Causes Of Lipoma

However, there is no exact cause of Lipoma, but the following are the factors involved in Lipoma development.

Medical Conditions

Lipomas can grow as a result of underlying medical conditions and hormonal imbalances. These are some of the diseases:

  • The Dercums disease
  • Gardner Disease
  • Madelung’s illness.
  • The Cowden Syndrome
  • Bannayan-Riley-Ruvalcaba
  • Multiple hereditary lipomatosis

Except for Dercums disease, these underlying medical conditions result from an altered genetic activity. It causes fatty cells to accumulate in areas such as the arms, torso, legs, chest, neck, and shoulders.

However, Dercums disease is more common in women. It is caused by an autoimmune response that attacks healthy tissues and causes fat to be stored beneath the skin.

Lipoma affects most women due to hormonal imbalances, such as high estrogen and growth hormone levels. Furthermore, long-term use of steroids can cause the growth of fatty tissues in various parts of the body.


As previously stated, many genetic diseases play a critical role in the occurrence of lipoma in various parts of the body. Some specific somatic and RB1 gene alterations are found in lipoma examination, indicating a strong link between genetic structures and lipoma. 


According to some studies, a poor diet with oily or fatty foods and low in vegetables and protein may contribute to lipoma growth. Furthermore, inflammatory foods, such as refined grains, fried foods, sweetened foods and drinks, and soda, can contribute. 

Excessive alcohol consumption is also a factor, as it causes Madelung’s disease in men, resulting in lipoma formation. Most people get a fatty liver disease from a high-fat diet and get lipomas built up on their liver surface.


Lipomas are most common in women between 35 and 50 who are obese and have high-fat levels. Furthermore, if an obese person has other medical conditions, they are more likely to develop a lipoma.

High cholesterol

High levels of lipids from fat cells in the bloodstream indicate high cholesterol. High levels of fat cells (LDL and HDL) in the blood show a higher probability that fat will accumulate in various parts of the skin with blood vessels.


Diabetes mellitus is caused by high glucose levels in the blood. High glucose levels increase inflammation and fat production, leading to benign and, in some cases, cancerous tumors.

Furthermore, repeatedly injecting insulin into the same area can cause scar tissue and fat cells to begin lipoma growth.

Past Injury 

A tumor can develop from a previous injury or any location of surgery/operation. Dead tissues and fat cells frequently accumulate at these sites, which is, without a doubt, a major cause of benign tumors.

Lack Of Activity Levels

Even if a person is not obese or overweight but is sedentary, this can be a major cause of lipoma. It majorly affects people aged 40-60, indicating inactivity at this age, and slow blood circulation throughout the body, allowing fat cells to accumulate.

Final Thoughts

It is obvious that lipomas are harmless, but it is always better to take care of them and not let them grow, as they can become a hindrance in daily life. Lipoma should not be confused with Cushing’s syndrome or liposarcomas, which require different treatments and procedures.

However, it is best to consult a doctor whenever you notice a lump, especially if it is causing pain. Most removal surgeries can be performed easily at the Rejuvence Clinic and other medical centers, making it less stressful.

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